I disagree with you, snooty, on the choice of sauceror as a first hardcore run - Disco bandit is a good option for the advanced cocktailcrafting which gives a good improvement in stat return compared to 'normal' booze along with a pile of extra adventures, which is nice. Also, as you are only worried about one stat (moxie) the run is a lot less complicated and allows you to decide whether you are really cut out for the hardcore life. After that, probably Sauceror or Turtle Tamer (for the passive familiar weight increase).
Disco Bandits are an excellent choice for hardcore as they have the pickpocket ability, particularly useful in the hippy fruit stall sidequest at level 12 where the glands can be pickpocketed - drastically improves your chances of picking up the next gland needed before your current one runs out.
Also, in relation to the level 12 side-quests, using meat vortexes against the bandits is extremely helpful - the nuns take away all the meat that drops normally, but combat using a meat vortex yields between 0 and the base amount of meat the bandits have (something in the region of a 1000) which you *do* get to keep - it can be essential to generating the meat to buy some of the more expensive skills to help you through the level 12 quest generally.
Most people know about the Arena side-quest quick win in terms of preparing the guy made of bees and slapping a flyer on him for a one-shot quest complete. If you happen to have both sets of gear available (frat and hippy) at level 12, you can do this sidequest as a frat boy to get access to the +meat buff before changing gear and completing the nun quest as a hippy.
A big part of the NS13 game is making best use of the semi-rare adventures that crop up. There is a script available for you Greasemonkey users that can predict when the next one will occur after you eat at least 2 fortune cookies. Useful ones to pick up are lunchboxes, inhalers, pet snacks and mystic shell. Why mystic shell? The massive damage absorption offered by it is extremely helpful against the gremlins - they always hit anyway so you might as well reduce the damage caused each time in order to allow the maximum chances to encounter the molybdenum tool.
Also, it is worth noting that semi-rare adventures occur more frequently in hardcore than softcore, and initial research indicates that going oxygenarian increases their frequency also (to roughly one semi-rare adventure every 100-110 turns).
I've been doing a bit of spading on the level 12 battlefield and it seems to me that the 'heroes' are randomly allocated a number between 1 and 1000 (999?). If your battlecounter equals that number then you get the adventure. This would indicate that if you spend the full 1000 turns defeating everyone then you will encounter all the heroes, with the more sidequests you do decreasing the chances significantly. I haven't come up with a way of exploiting this yet

though if you are after a specific item (like the natty blue ascot) then you *will* encounter it if you go slow...and given mall prices for ascots this means that you could easily pull in the meat to buy a Mr A each month providing you can complete a run in under around 10 days

Hmmm...a somewhat long post. Oh well, hopefully it's helpful

Edit: It might be helpful to link in Lechef's Ronin Guide to the original post too